Recombinant CD25 Monoclonal Antibody

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.

IMD; IDDM; IL2RA; CD25; IDDM10; IL2R; IMD41; TCGFR; p55; IL-2 receptor subunit alpha; IL-2R subunit alpha; IL2-RA; IL-2-RA; IL-2Rα; Interleukin-2 receptor subunit alpha; TAC antigen; Tac; p55; IL-2Rα alpha chain; CD25 antigen; IL 2 receptor alpha subunit; IL2 RA; Interleukin 2 receptor; Interleukin 2 receptor alpha; Interleukin 2 receptor alpha chain; t-cell growth factor receptor