Recombinant CCR6 Monoclonal Antibody

Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma.

DCR; DRY; GPR; CKRL; STRL; CKR-L; CMKBR; GPRCY; CC-CKR; C-C CKR; CCR; CCR6; BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22; BN 1; BN1; C C chemokine receptor type 6; C C CKR 6; CC chemokine receptor type 6; C-C chemokine receptor type 6; CC CKR 6; CC R6; CCCKR6; CCR 6; CD 196; CD196 antigen; Chemokine (C C motif) receptor 6; Chemokine (C C) receptor 6; Chemokine (CC motif) receptor 6; Chemokine (CC) receptor 6; Chemokine receptor 6; Chemokine receptor like 3; Chemokine receptor-like 3; CKR 6; CKR L3; CKR6; CMKBR 6; DCR 2; DRY 6; G protein coupled receptor 29; GPR 29; GPR CY4; GPRCY 4; GPR-CY4; G-protein coupled receptor 29; LARC receptor; Seven transmembrane receptor lymphocyte 22; STRL 22