Recombinant CBP Monoclonal Antibody
Product Specifications
Background
CREB-binding protein (CREBBP/CBP), encoded by the human CREBBP gene, is a transcriptional co-activator. CREBBP functions through interactions with transcription factors, mediated by one or more domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3), and the interferon response binding domain. The KIX, TAZ1, and TAZ2 domains of CREBBP bind tightly to the 9aaTADs, the nine amino acid transactivation domains within the tumor suppressor protein p53, thereby influencing its transcriptional activity.
Abbreviation
CBP
UniProt
Q92793
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide derived from the human CBP protein
Target
CREBBP; CBP; KAT3A; RSTS; RSTS1; CREB binding protein; CREB-binding protein; Cyclic AMP responsive enhancer binding protein; RTS; Rubinstein Taybi syndrome
Clonality
Monoclonal,Recombinant
Clone
A152
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Epigenetics and Nuclear Signaling; Microbiology; Stem Cells; Cancer; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:1000-1:3000; IF 1:100-1:200
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
300 kDa
Observed Molecular Weight
300 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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