Recombinant Androgen Receptor (CT) Monoclonal Antibody
Product Specifications
Background
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.9 Publications Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Abbreviation
Androgen Receptor
UniProt
P10275
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide derived from Androgen Receptor (AR) (C-term) anti
Target
HYSP; NR3C; SMAX; AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; AR; AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; AR; Group C; Member 4; Nuclear Receptor Subfamily 3
Clonality
Monoclonal,Recombinant
Clone
A132
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Developmental Biology
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/rDuIxVHV
Calculated Molecular Weight
99 kDa
Observed Molecular Weight
120 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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