Recombinant AKT1 Monoclonal Antibody
Product Specifications
Background
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Abbreviation
AKT1
UniProt
P31749
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Recombinant human AKT1 fragment
Target
CWS; MGC; AKT serine/threonine kinase; AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; AKT1; AKT 1; AKT serine/threonine kinase 1; AKT1_HUMAN; MGC99656; Protein kinase B; Protein Kinase B Alpha; Proto-oncogene c-Akt; RAC Alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; AKT; AKT serine/threonine kinase 1; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
Clonality
Monoclonal,Recombinant
Clone
A123
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism; Neuroscience
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
60 kDa
Observed Molecular Weight
60 kDa
Isotype
IgG, κ
Available Sizes
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