Recombinant SOD2 (Acetyl Lys68) Monoclonal Antibody
Product Specifications
Background
Manganese superoxide dismutase (MnSOD), also named as SOD2, is a mitochondrial detoxification enzyme that catalyzes the conversion of superoxide to hydrogen peroxide. Hydrogen peroxide is then decomposed to water by catalase, glutathione peroxidase, or peroxiredoxins. MnSOD and other enzymes involved in antioxidant defense protect cells from reactive oxygen species (ROS) . Calorie restriction leads to SIRT3-mediated deacetylation of MnSOD and the subsequent increase of its antioxidant activity. MnSOD also plays an essential role in mediating the protective effect of mTOR inhibition to reduce epithelial stem cell senescence.
Abbreviation
SOD2 (Acetyl Lys68)
UniProt
P04179
Host
Rabbit
Reactivity
Human; Rat; Mouse
Immunogen
Acetylated human histone SOD2 (Lys68) peptide
Target
SOD; MVCD; superoxide dismutase; IPO-B; IPOB; MNSOD; MVCD6; Mn-SOD; SOD2; Superoxide Dismutase [Mn] Mitochondrial; superoxide dismutase 2; IPOB; IPO-B; MNSOD; Mn-SOD; MVCD6; superoxide dismutase 2; EC:1.15.1.1; mitochondrial; Superoxide dismutase [Mn]
Clonality
Monoclonal,Recombinant
Clone
A107
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cell Biology; Signal Transduction; Neuroscience; Cardiovascular; Cancer; Metabolism
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
20 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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