Recombinant SREBP-1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Abbreviation
SREBP-1
UniProt
P36956
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human SREBP-1 protein
Target
BHLHD; SREBP; SREBF; BHLHD1; SREBP1; SREBF1
Clonality
Monoclonal,Recombinant
Clone
11A12
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cardiovascular; Epigenetics and Nuclear Signaling; Cancer; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/wpznRa1N
Isotype
IgG, κ
Curated Selection
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