Recombinant DDR1 Monoclonal Antibody

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

RTK; HGK; MCK; PTK; EDDR; NTRK; CD167; DDR; HGK2; MCK10; PTK3; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; DDR1; CD 167; CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DDR; DDR 1; Discoidin domain receptor; Discoidin domain receptor tyrosine kinase 1; Discoidin receptor tyrosine kinase; Discoidin receptor tyrosine kinase isoform a; EDDR 1; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; Epithelial specific receptor kinase; Mammarian carcinoma kinase 10; Mammary carcinoma kinase 10; MCK-10; Neuroepithelial tyrosine kinase; Neurotrophic tyrosine kinase receptor type 4; NTRK 4; OTTHUMP00000029343; OTTHUMP00000029344; OTTHUMP00000029345; OTTHUMP00000029346; OTTHUMP00000029347; OTTHUMP00000164863; OTTHUMP00000164867; OTTHUMP00000222080; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; PTK 3; PTK 3A protein tyrosine kinase 3A; Receptor tyrosine kinase NEP; RTK 6; TRK E; Tyrosine kinase DDR; Tyrosine kinase receptor E; Tyrosine-protein kinase CAK