Recombinant xCT Monoclonal Antibody
Product Specifications
Background
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Abbreviation
XCT
UniProt
Q9UPY5
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human xCT protein
Target
CCBR; SLC7A; SLC7A11; CCBR1; xCT; (cationic amino acid transporter; Amino acid transport system xc-; Amino acid transport system xc xCT; Calcium channel blocker resistance protein CCBR1; Cysteine/glutamate transporter; Cystine/glutamate transporter; member 11; OTTHUMP00000164578; solute carrier family 7; Solute carrier family 7 (anionic amino acid transporter light chain; Solute carrier family 7 member 11; SYSTEM Xc (-) TRANSPORTER-RELATED PROTEIN; xc- system) ; y+ system) member 11; SLC7A11
Clonality
Monoclonal,Recombinant
Clone
6F6
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cell Biology; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
37 kDa
Observed Molecular Weight
55 kDa
Isotype
IgG, κ
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