Recombinant xCT Monoclonal Antibody

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

CCBR; SLC7A; SLC7A11; CCBR1; xCT; (cationic amino acid transporter; Amino acid transport system xc-; Amino acid transport system xc xCT; Calcium channel blocker resistance protein CCBR1; Cysteine/glutamate transporter; Cystine/glutamate transporter; member 11; OTTHUMP00000164578; solute carrier family 7; Solute carrier family 7 (anionic amino acid transporter light chain; Solute carrier family 7 member 11; SYSTEM Xc (-) TRANSPORTER-RELATED PROTEIN; xc- system) ; y+ system) member 11; SLC7A11