Recombinant TGF β Receptor II Monoclonal Antibody

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.

MFS; LDS; FAA; AAT; TAAD; TGFR; TGF-beta receptor type; TGFBR; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII; TGF beta Receptor II; TGFBR2; TGF-beta receptor type-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; Tgfbr2; beta receptor II (70/80kDa) ; beta receptor II alpha; beta receptor II beta; beta receptor II delta; beta receptor II epsilon; beta receptor II gamma; TbetaR II; TbetaR-II; TBRII; TBR-ii; TGF beta receptor type 2; TGF beta receptor type II; TGF beta receptor type IIB; TGF beta type II receptor; TGFB R2; TGFbeta - RII; TGF-beta receptor type II; TGFbeta RII; TGF-beta-R2; TGFR2; Transforming growth factor; transforming growth factor beta receptor 2; Transforming growth factor beta receptor II; Transforming growth factor beta receptor type II; Transforming growth factor beta receptor type IIC