Recombinant 53BP1 Monoclonal Antibody

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

53BP; TDRD; tumor protein p53 binding protein; p53BP; TP53BP; TP53BP1;53BP1; TDRD30; TP53; p202; p53BP1; tumor protein p53 binding protein 1;53BP1; p202; p53BP1; TDRD30; TP53; tumor protein p53 binding protein 1