Recombinant 53BP1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
Abbreviation
53BP1
UniProt
Q12888
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human 53BP1 protein
Target
53BP; TDRD; tumor protein p53 binding protein; p53BP; TP53BP; TP53BP1;53BP1; TDRD30; TP53; p202; p53BP1; tumor protein p53 binding protein 1;53BP1; p202; p53BP1; TDRD30; TP53; tumor protein p53 binding protein 1
Clonality
Monoclonal,Recombinant
Clone
5F5
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000; IHC 1:200-1:1000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
214 kDa
Observed Molecular Weight
450 kDa
Isotype
IgG, κ
Curated Selection
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