Recombinant Phospho-β Catenin (Ser675) Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Abbreviation
Β Catenin
UniProt
P35222
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide corresponding to residues around (Ser675) of Human Phospho-β Catenin
Target
MRD; PRO; Catenin beta; SW-cl; OK/SW-cl; CTNNB; MRD19; armadillo; beta Catenin; CTNNB1; Beta-catenin; Catenin beta-1; OK; SW-cl.35; OK/SW-cl.35; PRO2286;88kDa; beta 1; Cadherin associated protein; Catenin (cadherin associated protein) ; Catenin beta 1; CATNB; CHBCAT; CTNB1; DKFZp686D02253; FLJ25606; FLJ37923; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289; Catenin β
Clonality
Monoclonal,Recombinant
Clone
7C7
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Neuroscience; Stem Cells; Cancer; Cardiovascular
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/gtDaqxT6
Calculated Molecular Weight
85 kDa
Observed Molecular Weight
85 kDa
Isotype
IgG, κ
Curated Selection
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