D-Alanine

D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR[1][2].

Product Specifications

CAS Number

[338-69-2]

Product Name Alternative

(R) -Alanine; Ba 2776; D-α-Alanine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/D-Alanine.html

Purity

99.92

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 120 mg/mL (ultrasonic)

Smiles

N[C@@H](C(O)=O)C

Molecular Formula

C3H7NO2

Molecular Weight

89.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48 (5) :919-27.|[2]Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113 (1) :165-70.|[3]Mao Horio, et al. Effects of D-Amino Acid Oxidase Inhibitor on the Extracellular D-Alanine Levels and the Efficacy of D-Alanine on Dizocilpine-Induced Prepulse Inhibition Deficits in Mice. The Open Clinical Chemistry Journal, 2009, 2: 16-21