Recombinant Phospho-IGF1R (Tyr1135/1136) /Phospho-Insulin Receptor β (Tyr1150/1151) Monoclonal Antibody
Selected Variant
AN301299L
Size: 100 µL
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Abbreviation
IGF1R
UniProt
P06213; P08069
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide corresponding to residues around (Tyr1135/1136) / (Tyr1150/1151) of Human Phospho-IGF1R/Phospho-Insulin Receptor β
Target
HHF; CD220; HHF5; INSR; IR; Insulin R; INSR; IR; Insulin Receptor; IGF IR; Insulin Receptor β
Clonality
Monoclonal, Recombinant
Clone
5C10
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Neuroscience; Cancer; Cardiovascular; Metabolism; Developmental Biology
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
156 kDa
Observed Molecular Weight
95 kDa
Isotype
IgG, κ
Price
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