Recombinant Actinin-α1 Monoclonal Antibody

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

ACTN; Non-muscle alpha-actinin; BDPLT; ACTN1; BDPLT15; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1; actinin; actinin 1 smooth muscle; Actinin alpha 1; ACTN 1; alpha 1; Alpha Actinin 1; Alpha actinin cytoskeletal isoform; Alpha-actinin-1; F actin cross linking protein; FLJ40884; FLJ54432; Non muscle alpha actinin 1; Actinin-α1