Recombinant Trk A Monoclonal Antibody
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Abbreviation
Trk A
UniProt
P04629
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Trk A protein
Target
NTRK; NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; Neurotrophic tyrosine kinase receptor type 1; Oncogene TRK; p140 TrkA; p14-TrkA; Slow nerve growth; Trk A; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk A
Clonality
Monoclonal,Recombinant
Clone
4D4
Conjugation
Unconjugated
Applications
IHC
Field of Research
Neuroscience; Cancer; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
Available Sizes
Curated Selection
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