Recombinant Trk A Monoclonal Antibody

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

NTRK; NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; Neurotrophic tyrosine kinase receptor type 1; Oncogene TRK; p140 TrkA; p14-TrkA; Slow nerve growth; Trk A; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk A