Recombinant GluR-2 Monoclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca (2+) . Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology.

GRIA; GLUR; GluA; HBGR; GluR-K; GRIA2; GLUR2; GLURB; GluA2; GluR-K2; HBGR2; AMPA 2; AMPA selective glutamate receptor 2; AMPA2; AMPA-selective glutamate receptor 2; GLUR 2; GLUR B; GluR K2; GluR-2; GluR-B; Glutamate receptor 2; Glutamate receptor ionotropic; Glutamate receptor ionotropic AMPA 2; GluR-2