Recombinant Bmi-1 Monoclonal Antibody
Product Specifications
Background
BMI1 proto-oncogene, polycomb ring finger (BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1) . This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Abbreviation
Bmi-1
UniProt
P35226
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Bmi-1 protein
Target
RNF; BMI; PCGF; flvi-2/bmi; FLVI2/BMI; BMI1; FLVI2/BMI1; PCGF4; RNF51; flvi-2/bmi-1; Bmi-1
Clonality
Monoclonal,Recombinant
Clone
7B9
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Stem Cells; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:100-1:500
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG, κ
Available Sizes
Curated Selection
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