Recombinant AMPKβ1 Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Abbreviation
AMPKβ1
UniProt
Q9Y478
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human AMPKβ1 protein
Target
5'-AMP-activated protein kinase subunit beta; PRKAB; PRKAB1; AMPK; HAMPKb;5'-AMP-activated protein kinase subunit beta-1;5'-AMP-activated protein kinase subunit beta-1; AMPK; HAMPKb; AMPKβ1
Clonality
Monoclonal,Recombinant
Clone
5H6
Conjugation
Unconjugated
Applications
IHC
Field of Research
Signal Transduction; Cardiovascular; Cancer; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:100-1:500
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/t3RGLHwq
Isotype
IgG, κ
Available Sizes
Curated Selection
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