Recombinant FRS2 Monoclonal Antibody
Product Specifications
Background
Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1., PTM:Phosphorylated on tyrosine residues upon stimulation by NGF., PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination., sequence caution:Translated as stop., similarity:Contains 1 IRS-type PTB domain., subcellular location:Cytoplasmic, membrane-bound., subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity) . Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11., tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Abbreviation
FRS2
UniProt
Q8WU20
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human FRS2 protein
Target
FRS; FRS2; FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; fibroblast growth factor receptor substrate 2; FRS2
Clonality
Monoclonal,Recombinant
Clone
9D10
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/el7rYgdX
Calculated Molecular Weight
57 kDa
Observed Molecular Weight
80 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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