Recombinant CUL4A/B Monoclonal Antibody
Product Specifications
Background
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]) .[supplied by OMIM, Oct 2009], CUL4B is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
Abbreviation
CUL4A/B
UniProt
Q13619; Q13620
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human CUL4A/B protein
Target
CUL4A; cullin-4A;2810470J21Rik; AW495282; CUL 4A; CUL-4A; Cul4a protein; MGC36573; MGC64071; CUL4A/B
Clonality
Monoclonal,Recombinant
Clone
9D6
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cell Biology
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000; WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
88104 kDa
Observed Molecular Weight
88 kDa,104 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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