Recombinant TRAF2 Monoclonal Antibody
Product Specifications
Background
TNF receptor associated factor 2 (TRAF2) Homo sapiens The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation.
Abbreviation
TRAF2
UniProt
Q12933
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human TRAF2 protein
Target
MGC; TRAF; TNF receptor-associated factor; MGC:45012; TRAP; TRAP3; TRAF2; TNF receptor-associated factor 2; MGC:45012; TNF receptor-associated factor 2; TRAP; TRAP3; TRAF2
Clonality
Monoclonal,Recombinant
Clone
12F10
Conjugation
Unconjugated
Applications
WB
Field of Research
Cell Biology; Signal Transduction; Cancer; Cardiovascular
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
56 kDa
Observed Molecular Weight
56 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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