Recombinant Drosha Monoclonal Antibody
Product Specifications
Background
DROSHA (drosha ribonuclease III) Homo sapiens This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer.
Abbreviation
Drosha
UniProt
Q9NRR4
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Drosha protein
Target
ETOHI; DROSHA; ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN; Drosha double stranded RNA specific endoribonuclease; Drosha ribonuclease type III; Nuclear RNase III Drosha; p241; Protein Drosha; Putative protein p241 which interacts with transcription factor Sp1; Putative ribonuclease III; Ribonuclease 3; Ribonuclease III; Ribonuclease III nuclear; Ribonuclease type III nuclear; RibonucleaseIII; RN 3; RNase 3; RNase III; RNase3; RnaseIII; RNaseIII; RNC; Drosha
Clonality
Monoclonal,Recombinant
Clone
11G11
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000; WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
159 kDa
Observed Molecular Weight
159 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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