Recombinant Nibrin Monoclonal Antibody
Product Specifications
Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Abbreviation
Nibrin
UniProt
O60934
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Nibrin protein
Target
MGC; Cell cycle regulatory protein p; Nijmegen breakage syndrome protein; NBN; AT-V1; AT-V2; ATV; NBS; NBS1; P95; nibrin; AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; MGC87362; NBS 1; Nijmegen breakage syndrome; Nijmegen breakage syndrome 1 (nibrin) ; Nijmegen breakage syndrome protein 1; p95 protein of the MRE11/RAD50 complex; ATV; AT-V1; AT-V2; NBS; NBS1; nibrin; P95; Nibrin
Clonality
Monoclonal,Recombinant
Clone
11A8
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000; WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
85 kDa
Observed Molecular Weight
95 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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