Recombinant Collagen IV Monoclonal Antibody

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.

COL4A; POREN; alpha 1 chain; Arresten; COL4A1 NC1 domain; Collagen alpha-1 (IV) chain; Collagen IV alpha-1 polypeptide; Collagen of basement membrane; HANAC; ICH; POREN1; COL4A1; Type-IV Collagen