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Recombinant PKM Monoclonal Antibody

Product Specifications

Background

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.

Abbreviation

PKM

UniProt

P14618

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Human PKM protein

Target

OIP; THBP; HEL-S; CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1; PKM; p58; PK2; CTHBP; OIP3; p58; PKM2; TCB; THBP1; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; Cytosolic thyroid hormone-binding protein (CTHBP) ; KPYM; MGC3932; muscle 2; muscle type; OIP 3; OIP-3; OPA interacting protein 3; Opa-interacting protein 3; Opa-interacting protein 3 (OIP-3) ; PK muscle type; pykm; Pyruvate kinase; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozymes M1/M2; pyruvate kinase M1/2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; pyruvate kinase PKM; Threonine-protein kinase PKM2; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Thyroid hormone-binding protein 1 (THBP1) ; Tumor M2 PK; Tumor M2-PK; PKM2

Clonality

Monoclonal,Recombinant

Clone

6A7

Conjugation

Unconjugated

Applications

WB; IHC

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism; Cardiovascular

Purification

Protein A

Concentration

0.2 mg/mL

Dilution

IHC 1:200-1000; WB 1:1000-5000

Buffer

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

57 kDa

Observed Molecular Weight

57 kDa

Isotype

IgG, κ

Available Sizes

Curated Selection

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