Recombinant PKM Monoclonal Antibody
Product Specifications
Background
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
Abbreviation
PKM
UniProt
P14618
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human PKM protein
Target
OIP; THBP; HEL-S; CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1; PKM; p58; PK2; CTHBP; OIP3; p58; PKM2; TCB; THBP1; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; Cytosolic thyroid hormone-binding protein (CTHBP) ; KPYM; MGC3932; muscle 2; muscle type; OIP 3; OIP-3; OPA interacting protein 3; Opa-interacting protein 3; Opa-interacting protein 3 (OIP-3) ; PK muscle type; pykm; Pyruvate kinase; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozymes M1/M2; pyruvate kinase M1/2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; pyruvate kinase PKM; Threonine-protein kinase PKM2; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Thyroid hormone-binding protein 1 (THBP1) ; Tumor M2 PK; Tumor M2-PK; PKM2
Clonality
Monoclonal,Recombinant
Clone
6A7
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism; Cardiovascular
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1000; WB 1:1000-5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
57 kDa
Observed Molecular Weight
57 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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