Recombinant IGF1 Receptor Monoclonal Antibody
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Abbreviation
IGF1 Receptor
UniProt
P08069
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Human IGF1 Receptor protein
Target
JTK; IGF1R; CD221; IGFIR; IGFR; JTK13; CD221 antigen; IGF-1R; IGF-I R; IGF-I receptor; IGF-IR; insulin-like growth factor 1 receptor; IGF-1R
Clonality
Monoclonal,Recombinant
Clone
6A5
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Cancer; Developmental Biology; Neuroscience; Cardiovascular; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:100-200; WB 1:1000-5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
154 kDa
Observed Molecular Weight
200 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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