Recombinant TMEM173 Monoclonal Antibody

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

NET; TMEM; TMEM173; ERIS; MITA; MPYS; NET23; SAVI; STING; hMITA; hSTING; Mediator of IRF3 activation; Stimulator of interferon genes protein; STING1; endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; FLJ38577; Mitochondrial mediator of IRF3 activation; N terminal methionine proline tyrosine serine plasma membrane tetraspanner; Stimulator of interferon genes; TM173; Transmembrane protein 173