Recombinant Optineurin Monoclonal Antibody
Product Specifications
Background
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Abbreviation
Optineurin
UniProt
Q96CV9
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Optineurin protein
Target
FIP; HIP; ALS; OPTN; ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP; Optineurin; OPTN
Clonality
Monoclonal,Recombinant
Clone
1F13
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Immunology; Signal Transduction; Neuroscience
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-500; WB 1:1000-5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
63 kDa
Observed Molecular Weight
74 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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