Recombinant p27 KIP 1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4) .
Abbreviation
P27 KIP 1
UniProt
P46527
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human p27 KIP 1 protein
Target
KIP; MEN; CDKN; Cyclin-Dependent Kinase Inhibitor p; P27KIP; p27 KIP; CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1; p27 KIP 1; Cyclin-Dependent Kinase Inhibitor 1B; Cyclin-Dependent Kinase Inhibitor p27; AA408329; AI843786; Cdki1b; CDKN 1B; CDKN 4; CDN1B; Cyclin Dependent Kinase Inhibitor 1B; Cyclin dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B (p27; Cyclin-dependent kinase inhibitor p27 Kip1; KIP 1; Kip1) ; OTTHUMP00000195098; OTTHUMP00000195099; p27; p27 Kip1; P27-like cyclin-dependent kinase inhibitor; p27
Clonality
Monoclonal,Recombinant
Clone
3P8
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Cell Biology; Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:200-1:1000; WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product MSDS
https://789.bio/eb/HDTBNCns
Calculated Molecular Weight
27 kDa
Observed Molecular Weight
27 kDa
Isotype
IgG, κ
Available Sizes
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