Recombinant PERK Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Abbreviation
PERK
UniProt
Q9NZJ5
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human PERK protein
Target
EIF2AK; EIF2AK3; PEK; PERK; WRS; DKFZp781H1925; E2AK3; EC 2.7.11.1; eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase
Clonality
Monoclonal,Recombinant
Clone
12B11
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
125 kDa
Observed Molecular Weight
140 kDa
Isotype
IgG, κ
Available Sizes
Frequently Asked Questions
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