Recombinant TAK1 Monoclonal Antibody

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

TAK; FMD; MEKK; MAP3K; CSCF; FMD2; MEKK7; TAK1; TGF1a; MAP3K7; M3K7; MAP3K 7; Mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; TGF beta activated kinase 1; TGF-beta-activated kinase 1; Transforming growth factor beta activated kinase 1; Transforming growth factor-beta-activated kinase 1