Recombinant HP1α Monoclonal Antibody
Product Specifications
Background
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Abbreviation
HP1α
UniProt
P45973
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human HP1α protein
Target
HEL; CBX; CBX5; HEL25; HP1; HP1A; Antigen p25; CG8409; Chromobox 5; Chromobox homolog 5; Chromobox homolog 5 (HP1 alpha homolog; Chromobox protein homolog 5; Drosophila) ; Epididymis luminal protein 25; Heterochromatin protein 1; Heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1 alpha homolog; HP1Hs alpha; Su (var) 205
Clonality
Monoclonal,Recombinant
Clone
4F3
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Epigenetics and Nuclear Signaling; Tags & Cell Markers
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
IHC 1:400-1:2000; WB 1:1000-1:5000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
22 kDa
Observed Molecular Weight
22 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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