Recombinant HP1α Monoclonal Antibody

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.

HEL; CBX; CBX5; HEL25; HP1; HP1A; Antigen p25; CG8409; Chromobox 5; Chromobox homolog 5; Chromobox homolog 5 (HP1 alpha homolog; Chromobox protein homolog 5; Drosophila) ; Epididymis luminal protein 25; Heterochromatin protein 1; Heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1 alpha homolog; HP1Hs alpha; Su (var) 205