Recombinant CD38 Monoclonal Antibody

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.

CADPr hydrolase; ADP-ribosyl cyclase; cyclic ADP-ribose hydrolase; Acute lymphoblastic leukemia cells antigen CD; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; CD38; ADPRC 1; ADPRC1; Acute lymphoblastic leukemia cells antigen CD38; ADP ribosyl cyclase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen; CD38 molecule; CD38H; Cyclic ADP ribose hydrolase; EC 3.2.2.5; I-19; NIMR5 antigen; p45; ADP-ribosyl; T10; cyclase;2'-phospho-ADP-ribosyl cyclase;2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1 (ADPRC 1) ; Cyclic ADP-ribose hydrolase 1 (cADPr hydrolase 1) ; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase; ADP ribosyl cyclase; ADPRC1; CD38 antigen; CD38 molecule; CD38H; Cyclic ADP ribose hydrolase; EC 3.2.2.5; I-19; NIMR5 antigen; p45; T10; Acute lymphoblastic leukemia cells antigen CD38; ADP ribosyl cyclase; ADPRC1; CD38 antigen; CD38 molecule; CD38H; Cyclic ADP ribose hydrolase; EC 3.2.2.5; I-19; NIMR5 antigen; p45; T10; ADP ribosyl cyclase 1; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase; CD 38; CD38 antigen (p45) ; Cd38-rs1; Cyclic ADP ribose hydrolase 1; Ecto nicotinamide adenine dinucleotide glycohydrolase; I19 (mouse) ; Lymphocyte differentiation antigen CD38; NAD (+) nucleosidase; NIM-R5 antigen; NIMR5 antigen (mouse) ; OTTHUMP00000158633; OTTHUMP00000217743