Recombinant Smad4 Monoclonal Antibody

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE) . The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

DPC; MADH; MAD Homolog; SMAD family member; Mothers Against DPP Homolog; Deletion Target in Pancreatic Carcinoma; Mothers Against Decapentaplegic Homolog; hSMAD; SMAD4; DPC4; JIP; MADH4; MYHRS; SMAD family member 4; Deletion Target in Pancreatic Carcinoma 4; hSMAD4; MAD Homolog 4; Mothers Against Decapentaplegic Homolog 4; Mothers Against DPP Homolog 4; SMAD 4; DPC4; JIP; MADH4; MYHRS; SMAD family member 4; (Small) Mothers Against Decapentaplegic; Deleted in Pancreatic Carcinoma; Deleted in Pancreatic Carcinoma 4; Deleted in pancreatic carcinoma locus 4; DPC 4; Drosophila; homolog of; MAD mothers against decapentaplegic Drosophila homolog 4; MAD mothers against decapentaplegic homolog 4; MADH 4; Med; Medea; Mothers against decapentaplegic; OTTHUMP00000163548; SMA- and MAD-related protein 4; SMAD mothers against DPP homolog 4