Recombinant PUMA Monoclonal Antibody

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

BBC; PUMA; BBC3; BBC 3; BBC3_HUMAN; BCL 2 binding component 3; BCL2 binding component 3; Bcl-2-binding component 3; JFY 1; JFY1; JFY-1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; p53 up-regulated modulator of apoptosis; PUMA alpha; PUMA/JFY1