Recombinant CD11b Monoclonal Antibody

ITGAM (integrin subunit alpha M) Homo sapiens This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

MAC; SLEB; Leukocyte adhesion receptor MO; CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; ITGAM; CD11b/ITAM; Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; integrin &alpha-M-M; antigen CD11b (p170) |integrin alpha M|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit; MGC117044