Recombinant GCLC Monoclonal Antibody
Product Specifications
Background
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
Abbreviation
GCLC
UniProt
P48506
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human GCLC protein
Target
GSH; Glutamate cysteine ligase catalytic subunit; GCLC; GCL; GCS; GLCL; GLCLC; EC 6.3.2.2; Gamma ECS; Gamma glutamylcysteine synthetase; Gamma-ECS; Gamma-glutamylcysteine synthetase; GCS heavy chain; Glutamate cysteine ligase catalytic subunit; Glutamate--cysteine ligase catalytic subunit; GSH1; GCSc-γ
Clonality
Monoclonal,Recombinant
Clone
3G3
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cell Biology; Metabolism
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
73 kDa
Observed Molecular Weight
73 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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