Recombinant JNK1/2/3 Monoclonal Antibody

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

MAPK; PRKM; SAPK; JNK1A; JNK21B; MAPK8; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c; AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JNK 1; MAP kinase 8; MAPK 8; Mitogen activated protein kinase 8; mitogen-activated; Mitogen-activated protein kinase 8; MK08; p54 gamma; Protein kinase; Protein kinase JNK1; SAPK 1; SAPK gamma; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1