Recombinant HER2 Monoclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

TKR; ERBB; erb-b2 receptor tyrosine kinase; Receptor tyrosine-protein kinase erbB; Tyrosine kinase-type cell surface receptor HER; HER2/ErbB; HER; MLN; ERBB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; erb-b2 receptor tyrosine kinase 2; HER2/ErbB2; MLN19; Metastatic lymph node gene 19 protein; p185; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; Neu; erb-B2; CD340; erb-b2 receptor tyrosine kinase 2; HER2; HER-2; HER-2/neu; MLN 19; MLN19; NGL; TKR1; C erb B2/neu protein; CD340 antigen; Cerb B2/neu protein; CerbB2; ENV; ENVW; Erb b2 receptor tyrosine kinase 2; ERVWE1; HER 2; HER 2/NEU; Herstatin; HERV7Q; HERV-7q; HERVW; HERVWENV; HERV-W-ENV; Human epidermal growth factor receptor 2; NEU proto oncogene; neuro/glioblastoma derived oncogene homolog; neuro/glioblastoma derived oncogene homolog (avian) ; Neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; Proto-oncogene c-ErbB-2; Tyrosine kinase type cell surface receptor HER2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) ; V erb b2 avian erythroblastic leukemia viral oncoprotein 2; V erb b2 erythroblastic leukemia viral oncogene homolog 2; Verb b2 erythroblastic leukemia viral oncogene homolog 2