Recombinant Phospho-Raf-B (Thr401) Monoclonal Antibody

Product Specifications

Background

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

Abbreviation

Raf-B

UniProt

P15056

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide corresponding to residues around (Thr401) of Human Phospho-Raf-B

Target

RAFB; BRAF; B-RAF1; B-raf; BRAF1; NS7; RAFB1; serine/threonine-protein kinase B-raf; B-raf; BRAF1; B-RAF1; NS7; RAFB1; serine/threonine-protein kinase B-raf;94 kDa B raf protein; B raf 1; B Raf proto oncogene; B Raf proto oncogene serine threonine protein kinase; B RAF1; BRAF 1; B-Raf proto-oncogene serine/threonine-protein kinase (p94) ; cRmil; FLJ95109; MGC126806; MGC138284; Murine sarcoma viral (v-raf) oncogene homolog B1; Murine sarcoma viral v raf oncogene homolog B1; Oncogen BRAF; oncogene BRAF1; p94; proto-oncogene B-Raf; Proto-oncogene c-Rmil; RAFB 1; RMIL; serine/threonine kinase; v raf murine sarcoma viral oncogene homolog B; v raf murine sarcoma viral oncogene homolog B1; v-Raf murine sarcoma viral oncogene homolog B1