Recombinant Vinculin Monoclonal Antibody
Product Specifications
Background
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Abbreviation
Vinculin
UniProt
P18206
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human Vinculin protein
Target
CMH; HEL; Epididymis luminal protein; CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VINC; Vinculin; VCL; Mvinculin
Clonality
Monoclonal,Recombinant
Clone
10F9
Conjugation
Unconjugated
Applications
WB
Field of Research
Signal Transduction; Cardiovascular; Isotype; Loading Controls
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
124 kDa
Observed Molecular Weight
124 kDa
Isotype
IgG, κ
Available Sizes
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