Recombinant HNF-4α Monoclonal Antibody

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

HNF; FRTS; HNF4A; FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14; FLJ39654; hepatic nuclear factor; Hepatic nuclear factor 4 alpha; Hepatocyte nuclear factor 4; Hepatocyte nuclear factor 4 alpha; Hepatocyte nuclear factor 4-alpha; HNF 4; HNF 4 alpha; HNF-4-alpha; HNF4alpha10/11/12; MODY 1; Nuclear receptor subfamily 2 group A member 1; OTTHUMP00000031060; OTTHUMP00000031062; TCF 14; TCF-14; Tcf4; Transcription factor 14; Transcription factor HNF 4; Transcription factor HNF4; Transcription factor HNF-4; HNF4α