Recombinant PKR Monoclonal Antibody

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

PPP1R; EIF2AK1; PKR; PPP1R83; PRKR; Eif2ak2; Double stranded RNA activated protein kinase; double-stranded RNA-activated protein kinase; E2AK2; eIF-2A protein kinase 2; Eukaryotic translation initiation factor 2 alpha kinase 2; Eukaryotic translation initiation factor 2-alpha kinase 2; HGNC:9437; Interferon induced double stranded RNA activated protein kinase; Interferon inducible elF2 alpha kinase; Interferon inducible RNA dependent protein kinase; Interferon-induced; Interferon-inducible RNA-dependent protein kinase; MGC126524; P1/eIF2A protein kinase; P1/eIF-2A protein kinase; p68 kinase; Protein kinase interferon inducible double stranded RNA dependent; Protein kinase RNA activated; Protein kinase RNA-activated; Protein phosphatase 1 regulatory subunit 83; Serine/threonine protein kinase TIK; Tyrosine protein kinase EIF2AK2