Recombinant Phospho-Chk2 (Thr68) Monoclonal Antibody
Product Specifications
Background
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage.
Abbreviation
Chk2
UniProt
O96017
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide corresponding to residues around (Thr68) of Human Phospho-Chk2
Target
RAD; LFS; CHK; CDS; hCds; CHEK; HuCds; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; CHEK2; CDS 1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; CHEK 2; Chk 2; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe) ; HuCds 1; LFS 2; RAD 53; Rad53 homolog; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2
Clonality
Monoclonal,Recombinant
Clone
1A5
Conjugation
Unconjugated
Applications
WB
Field of Research
Epigenetics and Nuclear Signaling; Cancer
Purification
Protein A
Concentration
0.2 mg/mL
Dilution
WB 1:2000-1:10000
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
61 kDa
Observed Molecular Weight
61 kDa
Isotype
IgG, κ
Available Sizes
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