Recombinant Phospho-Chk2 (Thr68) Monoclonal Antibody

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage.

RAD; LFS; CHK; CDS; hCds; CHEK; HuCds; CDS1; CHK2; HuCds1; LFS2; PP1425; RAD53; hCds1; CHEK2; CDS 1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; CHEK 2; Chk 2; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe) ; HuCds 1; LFS 2; RAD 53; Rad53 homolog; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2