Recombinant OTUB2 Monoclonal Antibody

Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2) 's active-site cleft is sterically occluded by a novel loop conformation resulting in an oxyanion hole, which consists uniquely of backbone amides. Furthermore, the residues that orient and stabilize the active-site histidine of otubain 2 (OTUB2) are different from other cysteine proteases. This reorganization of the active-site topology provides a possible explanation for the low turnover and substrate specificity of the otubains.

OTB; OTU; OTUB; Ubiquitin Thioesterase OTUB; Deubiquitinating Enzyme OTUB; Ubiquitin-Specific-Processing Protease OTUB; OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein; C14orf; Otubain; Deubiquitinating Enzyme OTUB2; OTU Comain-Containing Ubiquitin Aldehyde-Binding Protein 2; Otubain-2; Ubiquitin Thioesterase OTUB2; Ubiquitin-Specific-Processing Protease OTUB2; C14orf137; OTB2; OTU2; OTUB2; FLJ21916; MGC3102; OTU domain; OTU domain containing ubiquitin aldehyde binding protein 2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain 2; ubiquitin aldehyde binding 2; Ubiquitin specific processing protease OTUB2; Ubiquitin specific protease otubain 2

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.