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Recombinant IkB alpha/NFKBIA Monoclonal Antibody

Product Specifications

Background

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Abbreviation

NFKBIA

UniProt

P25963

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant Human IkB alpha/NFKBIA Protein

Target

EDAID; MAD; IKBA; MAD-3; NFKBI; IKB alpha; NFKBIA; EDAID2; I kappa B alpha; IkappaBalpha; I-kappa-B-alpha; IKBalpha; IkB-alpha; MAD 3; NF kappa B inhibitor alpha; MAD3; alpha; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; pIκBα

Clonality

Monoclonal

Clone

5D10

Conjugation

Unconjugated

Applications

WB; IP

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Immunology

Purification

Protein A

Concentration

1 mg/mL

Dilution

WB 1:500-1:2000; IP 1-4 μL/mg of lysate

Buffer

0.2 μm filtered solution in PBS

Shipping Conditions

Ice bag

Storage Conditions

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

37 kDa

Observed Molecular Weight

38 kDa

Isotype

IgG

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